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DOAC – Maintain bone health and reduce the risks of osteoporosis and Alzheimer’s with Dr Vonda Wright!
Video 4 min read
In this in-depth conversation, Dr. Vonda Wright—a renowned orthopedic surgeon and longevity expert—discusses the intersection of musculoskeletal health, aging, and cognitive performance. She emphasizes a proactive and personalized approach to aging, health, and fitness through what she terms “precision longevity.” Her insights are rooted in decades of treating elite athletes...
2025-03-06 - by Steven Bartlett, Dr Vonda Wright
Implausibility of radical life extension in humans in the twenty-first century
Scientific Study 1 min read
Over the course of the twentieth century, human life expectancy at birth rose in high-income nations by approximately 30 years, largely driven by advances in public health and medicine. Mortality reduction was observed initially at an early age and continued into middle and older ages. However, it was unclear whether this...
2024-10-07 - by S. Jay Olshansky, Bradley J. Willcox, Lloyd Demetrius & Hiram Beltrán-Sánchez
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
Scientific Study 2 min read
A study published in Nature examined the gut microbiomes of 160 Japanese centenarians, individuals aged 100 years or older. Researchers discovered that these centenarians possessed a distinct composition of gut bacteria compared to younger age groups. Notably, their microbiomes were enriched with microorganisms capable of producing unique secondary bile acids....
2021-10-06 - by Yuko Sato, Koji Atarashi, Damian R. Plichta, Yasumichi Arai, Satoshi Sasajima, Sean M. Kearney, Wataru Suda, Kozue Takeshita, Takahiro Sasaki, Shoki Okamoto, Ashwin N. Skelly, Yuki Okamura, Hera Vlamakis, Youxian Li, Takeshi Tanoue, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Junichiro Irie, Hiroshi Itoh, Kyoji Moriya, Yuki Sugiura, Makoto Suematsu, Nobuko Moritoki, Shinsuke Shibata, Dan R. Littman, Michael A. Fischbach, Yoshifumi Uwamino, Takashi Inoue, Akira Honda, Masahira Hattori, Tsuyoshi Murai, Ramnik J. Xavier, Nobuyoshi Hirose & Kenya Honda
The Multiomics Blueprint of Extreme Human Lifespan
Scientific Study 3 min read
Summary of the Key Findings The researchers conducted a comprehensive multiomics analysis—encompassing genomic, transcriptomic, metabolomic, proteomic, microbiomic, and epigenomic studies—on a supercentenarian (referred to as M116) who lived to the remarkable age of 117 years. Despite exceeding average life expectancy by over three decades, M116 remained in notably good health...
2025-02-25 - by Eloy Santos-Pujol, Aleix Noguera-Castells, Marta Casado-Pelaez, Carlos A. García-Prieto, Claudia Vasallo, Ignacio Campillo-Marcos, Carlos Quero-Dotor, Eva Crespo-García, Alberto Bueno-Costa, Fernando Setién, Gerardo Ferrer, Veronica Davalos, Elisabeta Mereu, Raquel Pluvinet, Carles Arribas, Carolina de la Torre, Francisco Villavicencio, Lauro Sumoy, Isabel Granada, Natalie S. Coles, Pamela Acha, Francesc Solé, Mar Mallo, Caterina Mata, Sara Peregrina, Toni Gabaldón, Marc Llirós, Meritxell Pujolassos, Robert Carreras-Torres, Aleix Lluansí, Librado Jesús García-Gil, Xavier Aldeguer, Sara Samino, Pol Torné, Josep Ribalta, Montse Guardiola, Núria Amigó, Oscar Yanes, Paula Martínez, Raúl Sánchez-Vázquez, Maria A. Blasco, Jose Oviedo, Bernardo Lemos, Julia Rius-Bonet, Marta Torrubiano, Marta Massip-Salcedo, Kamal A. Khidir, Thong Huy Cao, Paulene A. Quinn, Donald J. L. Jones, Salvador Macip, Eva Brigos-Barril, Mauricio Moldes, Fabio Bartieri, Gerard Muntané, Hafid Laayouni, Arcadi Navarro, Manel Esteller